Any experienced pipetter knows that when pipetting, the smaller the dispense volume, the harder it is to achieve accurate and consistent results. Pipetting volumes below 2.0 µL can be frustratingly difficult; the smallest drop left behind, the slightest movement, or the quality of the individual tip can cause poor results. A pipette that fails calibration for one technician, may pass for another. Not all variables can be easily controlled, but here are some techniques and tips that can help improve performance!